During manufacturing, through a specific technological process the oral control release system simplifies the oral administration of the medicine that release gradually and steadily its active ingredients.
Decreases daily dosage (better therapeutic adherence).
Uniform and steady therapeutic levels.
Increases the plasma concentrations of short half-life active ingredients.
Combination of active ingredients with different release profiles in the same medicine.
pH independence (consistent
release) Protection of the active ingredient against gastric pH
TR–Caps: Time release pellets
IR–Caps: Immediate release pellets
GR–Caps: Gastro resistant pellets
Graph Number 1: Study of Bioavailability Nifedipine 30mg 24 hours. Source: Study of Bioavailability of Nifedipine 24 hours, Protocol BD100329-001, 03/29/2010.