During manufacturing, through a specific technological process the oral control release system simplifies the oral administration of the medicine that release gradually and steadily its active ingredients.
Benefits: Decreases daily dosage (better therapeutic adherence). Uniform and steady therapeutic levels. Increases the plasma concentrations of short half-life active ingredients. Combination of active ingredients with different release profiles in the same medicine. pH independence (consistent release) Protection of the active ingredient against gastric pH
RELEASE TECHNOLOGY TR–Caps: Time release pellets IR–Caps: Immediate release pellets GR–Caps: Gastro resistant pellets
Graph Number 1: Study of Bioavailability Nifedipine 30mg 24 hours. Source: Study of Bioavailability of Nifedipine 24 hours, Protocol BD100329-001, 03/29/2010.