During manufacturing, through a specific technological process the oral control release system simplifies the oral administration of the medicine that release gradually and steadily its active ingredients.

Benefits:

• Decreases daily dosage (better therapeutic adherence).
• Uniform and steady therapeutic levels.
• Increases the plasma concentrations of short half-life active ingredients.
• Combination of active ingredients with different release profiles in the same medicine.
• pH independence (consistent release)
• Protection of the active ingredient against gastric pH

RELEASE TECHNOLOGY

TR–Caps: Time release pellets

IR–Caps: Immediate release pellets

GR–Caps: Gastro resistant pellets

Graph Number 1: Study of Bioavailability Nifedipine 30mg 24 hours. Source: Study of Bioavailability of Nifedipine 24 hours, Protocol BD100329-001, 03/29/2010.